Training & Education

Fourth HeMiBio Winter School


13. January 2015 in Chur, SwitzerlandImage1
Organised by Prof. Mathieu Vinken, Prof Catherine Verfaillie, Dr. Leonardus van Grunsven and Dr. Pau Sancho-Bru

In Vitro Biokinetics

Within HeMiBio, we use different tissue culture set-ups that finally will be incorporated into 2D and/or 3D microfluidic bioreactors. Currently, different cell types as well as co-cultures of hepatic cells are developed as screening tools for the detection of apical endpoint pertinent to repeated dose toxicity, including liver steatosis, fibrosis and cholestasis. Most experiments are still carried out in regular 24/96 well plates, but a 2D bioreactor set-up is used as well. Among the parameters to be addressed during the evaluation of these cell systems and experimental set-ups is the effective concentration at which a certain adverse outcome can be observed. Indeed, compound concentrations that finally accumulate inside a cell need to be determined and compared with in vivo toxic doses. Several detectors are being developed to monitor a number of read-outs, such as pH, O2, glucose, lactate, ALT (glutamate), NH4+/urea.

During the workshop key questions concerning the bioreactor set-up such as how to measure the free concentration of coumpounds, the concentration inside the cells or of metabolites will be addressed.

Because of confidentiality issues the workshop is only open for SEURAT-1 members

Please contact This email address is being protected from spambots. You need JavaScript enabled to view it. should you be interested to participate.

Invited Speakers
Minne Heringa (PhD, ERT) - Centre for Safety of Substances and Products (VSP), RIVM - The National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Emanuela Testai (PhD), Istituto Superiore di Sanità, Environment & Primary Prevention Dept., Mechanisms of Toxicity Unit, Rome, Italy



21. - 22. January 2013 in Leuven, Belgium
From Stem Cells to Liver Cells

4. - 6. June 2013 - HeMiBio Workshop for young scientists in Brussels, Belgium
Practical concepts of in vitro and in silico toxicology


16. January 2013 - Second HeMibio Winterschool organised in Barcelona, Spain
Concepts of toxicology and risk assessment


16. - 17. January 2012 - First HeMibio Winterschool organised in Jerusalem, Israel
Introduction to Microfabrication Technology for Biology and Medicine




Training events are jointly funded by the European Commission and Cosmetics Europe through the HeMiBio project, contract number HEALTH-F5-2010-266777